Anti-CD32b [NOV0281]

Catalogue Number: AB03965-10.3-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD32; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; human FCGR2B
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	NOV0281
Isotype:	IgG1
Immunogen:	The original antibody was isolated from a human combinatorial antibody library by panning against biotinylated human CD32b.
Application:	ELISA, FC, InVitroA

Overview
Datasheets

Additional Text

Gene ID

2213

Gene Name

FCGR2B

Uniprot ID

P31994

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

The specificity of the antibody for CD32b was determined by ELISA analysis. The antibody was able to bind to CD32b expressed on human B cells by flow cytometry analysis (binding affinity 5.4 nM). The binding of the antibody to the BJAB cell line was evaluated by flow cytometry (binding affinity 2.4 nM). The antibody bound to CHO cells expressing huCD32b in flow cytometry analysis. The human IgG1 format of the antibody was evaluated for its activity in a primary NK cell based antibody-dependent cell-mediated cytotoxicity (ADCC) assay. The antibody demonstrated concentration dependent specific cell lysis of both cancer cell lines evaluated (Jeko-1 and Karpas422 Cancer Cell) (US20170198040A1).

Short Description

This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.

AB03965-10.3-BT Datasheet

Price

£1,825.00

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