Anti-VEGFR-3 [ABDD073]
Catalogue Number: AB04028-10.3-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | FLT-4; Vascular endothelial growth factor receptor 3; EC:2.7.10.1; Fms-like tyrosine kinase 4; Tyrosine-protein kinase receptor FLT4 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Human |
| Clone: | ABDD073 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing BALB/C mice with VEGFR-3/Ig recombinant protein. |
| Application: | ELISA, FC, IHC |
Additional Text
Gene ID
2324
Gene Name
FLT4
Uniprot ID
P35916
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The antibody showed neutralizing activity by ELISA analysis. The antibody detected VEGFR-3 from HEL cell lysates by western blot analysis. The antibody could recognize VEGRF-3 on fetal heart, fetal kidney and fetal lung tissue by immunohistochemistry. The binding activity of the antibody to VEGFR-3 expressed on the surface of HEL cells was confirmed by FACS flow cytometry. In vitro experiments showed the antibody could block the interaction between VEGFR-3 and VEGF-D. The antibody could inhibit HEL cell proliferation. The antibody could inhibit the generation of chicken embryo allantoic membrane blood vessels induced by recombinant GST-VEGF-D (CN1800373A).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB04028-10.3 Datasheet
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