Anti-Nkp46 [29A1.4]
Catalogue Number: AB04104-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD335; NK-p46; NKp46; mNKp46; mAR-1; Activating receptor 1; Lymphocyte antigen 94; Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | 29A1.4 |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated by immunizing rats with mouse NKp46-Fc recombinant protein. |
| Application: | FC, Act |
Additional Text
Gene Name
NCR1
Uniprot ID
Q8C567
Gene ID
17086
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The original format of this antibody was used in an FC analysis to detect NKp46 expression on NK cells and to activate NK in an NK cell stimulation assay (Walzer et al., 2007; PMID: 17360655). This antibody was used as a component of bispecific NKCEs (Natural Killer Cell Engagers) to redirect the cytotoxic activity of NK cells towards human CD20-expressing tumor cells in a transplantable xenogeneic in vivo solid tumor model (Gauthier et al., 2019; PMID: 31155232).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB04104-23.0 Datasheet
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