Anti-paraoxon (organophosphate) [A.17 L47K]
Catalogue Number: AB04213-23.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | L-Leu47Lys; A17 L47K; POX |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Rabbit |
| Clone: | A.17 L47K |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated via phage display from the Griffin.1 library by panning against reactive phosphonate ester 1. |
| Application: | Crstion |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody is a covalent trap for Paraoxon and other organophosphate substrates, catalyzing the hydrolysis reaction through the SN2 mechanism. The catalytic parameters of this antibody were measured, and its KD was found to be 170 +/- 8 µM; it exhibited a 340-fold reactivity enhancement for paraoxon relative to wild-type Ig-paraoxonase. Furthermore, its crystal structure in complex with paraoxon was determined (Mokrushina et al., 2020; PMID: 32859757).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
AB04213-23.0-BT Datasheet
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