Anti-HCEC [FC44]
Catalogue Number: AB04233-34.11-BS-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | VHH Nanobodies |
| Alias: | Human cerebromicrovascular endothelial cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Camelid |
| Clone: | FC44 |
| Isotype: | |
| Immunogen: | The original antibody was isolated from a naive phage displayed library of llama VHH. The library was panned against HCEC target cells. |
| Application: | ELISA, InVitroA, InVivoA |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The specificity of the original format of the antibody was confirmed by ELISA analysis (US8715659B2; Muruganandam et al., 2002; PMID: 11772942). The original format of the antibody bound to the vesicular and the membrane fractions of HCEC, and it was taken up by living HCEC, as shown by fluorescence microscopy. The antibody could transmigrate across an in vitro human blood-brain barrier (BBB) model. The antibody was also also detected in the brain after i.v. injection into mice (Muruganandam et al., 2002; PMID: 11772942). The antibody was able to transport across rat BBB, as demonstrated by in vitro and in vivo studies (Xiao et al., 2013; PMID: 23840214).
AB04233-34.11-BS Datasheet
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