Anti-IL-12/IL-23p40 [CNTO 1275 (Ustekinumab)]
Catalogue Number: AB04238-3.3-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | p40; IL-12; IL-12p40; IL-12B; IL-23; IL-23p40 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | CNTO 1275 (Ustekinumab) |
| Isotype: | IgG2b |
| Immunogen: | The original antibody was produced by immunizing human immunoglobulin transgenic mice ((CBA/JxC57/BL6/J) F2 hybrid) with human recombinant IL-12. |
| Application: | Blk, InVivoA |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody inhibits the interactions of IL-12 and IL-23 with the cell surface IL-12Rβ1 receptor and has been evaluated in phase I, II, and III trials as a treatment for immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn's disease, multiple sclerosis, and ulcerative colitis (Elliott et al., 2009; PMID: 20074279) (Sands et al., 2019; PMID: 31553833).
Short Description
This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
AB04238-3.3 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations