Anti-CXCR4 [14D09]
Catalogue Number: AB04368-23.159-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CXC-R4; CXCR-4; C-X-C chemokine receptor type 4; fusin; CD184; 2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS; WHIMS1; Leukocyte-derived seven transmembrane domain receptor |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Rabbit |
| Clone: | 14D09 |
| Isotype: | IgG |
| Immunogen: | |
| Application: | ELISA, FC |
Additional Text
Gene Name
CXCR4
Uniprot ID
P61073
Gene ID
7852
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding of the original version of this antibody (VHH) to CXCR4-expressing viral lipoparticles was characterized in an ELISA. Furthermore, it was analyzed for its ability to compete with the ligand CXCL12 (or SDF-1a) for receptor binding by displacement of biotinylated SDF-1 on Caki-CXCR4 cells in flow cytometry. This antibody exhibited medium affinity to its target (EC50/kD of 1 < x ≤ 10 nM) and a ligand inhibition (IC50 1 < x < 10 nM). In its bi-specific construction with clone 57A07, it served a functional role (US20220242958).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Alpaca VHH format, for improved compatibility with existing reagents, assays and techniques.
AB04368-23.159-BT Datasheet
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