Anti-M-CSF [5H4]
Catalogue Number: AB04376-10.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CSF-1; MCSF; PG-M-CSF; Lanimostim; Macrophage colony-stimulating factor; Macrophage colony-stimulating factor 1; Proteoglycan macrophage colony-stimulating factor |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Human |
| Clone: | 5H4 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | NT, SPR |
Additional Text
Gene ID
1435
Uniprot ID
P09603
Gene Name
Csf1
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding properties of the original format of the antibody were analyzed using SPR analyses (Kd = 3 nM). The antibody could neutralize human M-CSF activity, as measured by a proliferation assay with M-NFS-60 cell line. Further, the Fab fragment of the antibody was able to neutralize human M-CSF activity, but with less potency. The humanized variant of the antibody was constructed (EP1913028B1).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB04376-10.0 Datasheet
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