Anti-NA, Neuraminidase [NA-63]
Catalogue Number: AB04405-10.29-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | EC:3.2.1.18 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Human |
| Clone: | NA-63 |
| Isotype: | |
| Immunogen: | The original antibody was raised by taking B cells from influenza A survivors and vaccinees and immortalizing these. |
| Application: | ELISA, Inh, InVitroA, SPR, Crstapy |
Additional Text
Uniprot ID
R4NFR6
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The structure of the original version of this antibody was determined using cryo-EM and x-ray crystallography (Zhu et al., 2020; PMID:31757767) (Gilchuk et al., 2019; PMID:31757769). This antibody was used for an ELISA on the NA protein of influenza A (Gilchuk et al., 2019; PMID:31757769). The binding strength of this antibody to neuraminidase of influenza A was determined using surface plasmon resonance. This antibody was used for an egress inhibition assay on MDCK cells infected with influenza A. Here it showed its ability to inhibit egress at low concentrations. This antibody was used for a HDX-MS study. The N9 antigen showed hydrogen-deuterium exchange in the presence of this antibody (Gilchuk et al., 2019; PMID:31757769). This antibody was used for a fetuin-based ELLA NA activity assay. Here it showed inhibition of NA (Zhu et al., 2020; PMID:31757767).
Short Description
This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
AB04405-10.29 Datasheet
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