Anti-NA, Neuraminidase [NA-63]

Catalogue Number: AB04405-15.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	EC:3.2.1.18
Shipping Condition:	Blue Ice
Unit(s):	500 ug
Host name:	Human
Clone:	NA-63
Isotype:	IgM
Immunogen:	The original antibody was raised by taking B cells from influenza A survivors and vaccinees and immortalizing these.
Application:	ELISA, Inh, InVitroA, SPR, Crstapy

Overview
Datasheets

Additional Text

Uniprot ID

R4NFR6

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

The structure of the original version of this antibody was determined using cryo-EM and x-ray crystallography (Zhu et al., 2020; PMID:31757767) (Gilchuk et al., 2019; PMID:31757769). This antibody was used for an ELISA on the NA protein of influenza A (Gilchuk et al., 2019; PMID:31757769). The binding strength of this antibody to neuraminidase of influenza A was determined using surface plasmon resonance. This antibody was used for an egress inhibition assay on MDCK cells infected with influenza A. Here it showed its ability to inhibit egress at low concentrations. This antibody was used for a HDX-MS study. The N9 antigen showed hydrogen-deuterium exchange in the presence of this antibody (Gilchuk et al., 2019; PMID:31757769). This antibody was used for a fetuin-based ELLA NA activity assay. Here it showed inhibition of NA (Zhu et al., 2020; PMID:31757767).

Short Description

This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.

AB04405-15.0-BT Datasheet

Price

£2,215.00

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