Anti-Structural polyprotein [CHK152]
Catalogue Number: AB04433-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | p130 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | CHK152 |
| Isotype: | IgG |
| Immunogen: | The original version of this antibody was raised by immunizing an adult C57BL/6 mice deficient for interferon regulatory factor 7 with La Reunion 2006 OPY-1 strain of CHIKV. |
| Application: | ELISA, NT, Blk, InVitroA, InVivoA |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Gene ID
956308
Gene Name
CHIKVgp2
Application Notes
The structure of the original version of this antibody was determined using cryo-EM. Further the original version of this antibody was used for a neutralization assay on CHIKV and Vero cells (Sun et al., 2013; PMID:23577234) (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). The original version of this antibody was used for a prophylaxis study on immunodeficient Ifnar-/- C57BL/6 mice, which were infected with CHIKV (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). This antibody was used for an ELISA on diffent CHIKV virions (Pal et al., 2013; PMID:23637602). The ability of this antibody to reduce viral infection in rhesus macaques was assesed. It showed that it was indeed able to reduce the viral load in these animals (Pal et al., 2014; PMID:24829346). This antibody has shown its ability to block access to CHKV virions and to block the E2 surface glycoprotein from enzymatic cleavage by trypsin (Blijleven et al., 2022; PMID:35215863).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Uniprot ID
Q5XXP3, Q8JUX5
AB04433-23.0 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations