Anti-M-CSF [Camille]

Catalogue Number: AB04518-10.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	MCSF; CSF1; Macrophage colony-stimulating factor; Macrophage colony-stimulating factor 1; Lanimostim; Proteoglycan macrophage colony-stimulating factor 1; PG-M-CSF 1
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	Camille
Isotype:	IgG1
Immunogen:	The original antibody was selected from a commercially available phage display library. The library was panned against the receptor-binding domain of human M-CSF (rbdM-CSF).
Application:	ELISA, FACS, FC, Inh

Overview
Datasheets

Additional Text

Gene ID

1435

Uniprot ID

P09603

Gene Name

Csf1

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

The original version of this antibody (human IgG1) was tested for its specificity for human M-CSF and cross-reactivity for cynomolgus M-CSF using ELISA. KD values of 18 pM and 25 pM were measured. This antibody binds M-CSF expressed on cells, as shown in a FACS assay that exhibited an EC50 value of 6.1 nM and 14 nM against M-CSF-expressing transfected CHO cells and MDA-MB 231 cells, respectively. This antibody successfully inhibited human and cynomolgus M-CSF binding to recombinant human M-CSF receptor with an IC50 of 4.4 pM and 5.9 pM, respectively. This antibody successfully inhibited the proliferation of M-NFS-60 cells induced by recombinant and native human and cynomolgus M-CSF with an IC50 of 2.3 pM and 17.7 pM for recombinant and native human M-CSF, respectively, and 2.6 pM and 98.5 pM for recombinant and native cynomolgus M-CSF, respectively (US10081675B2).

AB04518-10.0-BT Datasheet

Price

£1,825.00

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Quantity
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