Anti-Alpha-synuclein [VH14 (NAC14)]

Catalogue Number: AB04611-34.11-BS-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	VHH Nanobodies
Alias:	SNCA; NACP; PARK1; alpha-syn; α-Synuclein; α-syn; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Camelid
Clone:	VH14 (NAC14)
Isotype:
Immunogen:	The original antibody was isolated from a naive repertoire of human scFv antibodies using yeast surface display to select binders against NAC peptide of human alpha-synuclein.
Application:	FA

Overview
Datasheets

Additional Text

Gene ID

6622

Gene Name

SNCA

Uniprot ID

P37840

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

The fusion of a proteasome-targeting PEST motif to this intrabody enhanced the solubility of the nanobody in cytoplasm and significantly enhanced degradation of the target protein, α-syn-GFP (PMID: 22929188). The in vivo therapeutic potential of gene therapy for delivery of proteasome-directed nanobodies selectively targeting α-syn was evaluated in a synuclein overexpression-based PD model. Post-mortem assessments of the substantia nigra (SN) of Sprague-Dawley rats after intracellular delivery of VH14-PEST showed that it markedly reduced the level of phosphorylated Serine-129 α-syn labeling relative to saline-treated animals (PMID: 30155513). A bifunctional antibody generated by fusing VH14 to a proteosome-targeting signal was able to counteract heterologous proteostatic effects of mutant α-Syn on mutant huntingtin Exon1 and protect against α-Syn toxicity using propidium iodide or Annexin V readouts (PMID: 27824888).

AB04611-34.11-BS Datasheet

Price

£3,895.00

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