Anti-Her2/neu [HerG1M]
Catalogue Number: AB04653-34.11-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | VHH Nanobodies |
| Alias: | CD340; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Camelid |
| Clone: | HerG1M |
| Isotype: | |
| Immunogen: | The original antibody was selected from a humanized VH single domain antibody gene library by screening against Her2/neu antigen. |
| Application: | ELISA, Inh, InVitroA, InVivoA |
Additional Text
Gene ID
2064
Gene Name
ERBB2
Uniprot ID
P04626
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding specificity of this humanized single-domain antibody (sdAb; VHH) was tested in an ELISA. This antibody was used to generate an anti-Her2/neu and anti-human Ig bi-specific construct together with Ab04651 [C3]. The bi-specific construct was tested in vitro on BT474 breast cancer cells using a CCK8 assay and demonstrated a significant inhibitory effect on the growth of the breast cancer cells (approximately 50 times more effective than Herceptin). The bi-specific construct also exhibited a significantly prolonged stability in vivo in mice compared to the sdAb version of the antibody (CN110964113B).
AB04653-34.11 Datasheet
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