Anti-ST2L [STLM62 (C2494)]

Catalogue Number: AB04660-23.0-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	ST2; IL1RL1; IL-1RL1; DER4; T1; IL-33Rα; Interleukin-1 receptor-like 1; Protein ST2; Growth Stimulation Expressed Gene 2; suppression of tumorigenicity 2
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rabbit
Clone:	STLM62 (C2494)
Isotype:	IgG
Immunogen:	The original antibody C2494 was generated by immunizing BALB/c mice with human ST2L-Fc fusion protein. Later on the mouse antibody was converted to human IgG2 chimeric antibody (STLM62).
Application:	ELISA, FC, FA, Blk, Ant

Overview
Datasheets

Additional Text

Gene ID

9173

Gene Name

IL1RL1

Uniprot ID

Q01638

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Short Description

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Application Notes

This antibody binds human ST2L and blocks the interaction between IL-33 and ST2L. This antibody was capable of recognizing recombinant human ST2L extracellular domain (ST2L-ECD) using an ELISA assay (PMID: 27294560). The original human IgG2 chimeric version of the antibody binds human and cynomolgus monkey ST2L with a binding affinity of 28 pM and 12 pM respectively (US9090694). This antibody was capable of binding ST2L expressed by LAD2 mast cells in a flow cytometric assay. This antibody was reported to block the IL-33 induced activation of NF-kB in a dose dependent manner. This antibody also blocked IL-1RAcP from binding to the ST2L/IL-33 complex. It can also inhibit cytokine secretion by human basophilic cell line KU812 (PMID: 27294560).

AB04660-23.0 Datasheet

Price

£430.00

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