Anti-HER2 [rhuMAB 2C4 (Pertuzumab)]
Catalogue Number: AB04911-3.3-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD340; ERBB2; MLN 1; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; p185HER2; OMNITARG; PERJETA |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Mouse |
| Clone: | rhuMAB 2C4 (Pertuzumab) |
| Isotype: | IgG2b |
| Immunogen: | The original antibody was generated by humanizing the murine 2C4 parental antibody. |
| Application: | ELISA, Inh, InVitroA, InVivoA, SPR |
Additional Text
Gene ID
2064
Gene Name
ERBB2
Uniprot ID
P04626
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding affinity of the original format of the antibody to HER2 was measured by surface plasmon resonance (Kd= 8.5 nM). The original format of the antibody was well tolerated in in vivo experiments with cynomolgus monkeys (Adams et al., 2005; PMID: 16151804). The original format of the antibody inhibited SK-BR-3 relative cell proliferation by about 20%. The original format of the antibody inhibited the generation of a HRG-induced tyrosine phosphorylation signal at Mr 180,000 (IC50= 2,8 nM). The antibody inhibited HRG binding to MCF7. The antibody was able to inhibit cell proliferation of MDA-MB-175 cells. The antibody blocked heregulin dependent association of ErbB3 with ErbB2 in both MCF7 and SK-BR-3 cells. The original format of the antibody was used for the treatment of the Calu-3 tumor-bearing mice, and it significantly inhibited the growth of the tumors. Furthermore, the combination of HERCEPTIN® and the original format of the antibody was superior to either monoclonal antibody administered alone. The original format of the antibody suppressed growth of colorectal xenografts and inhibited breast cancer tumor growth in vivo (US7862817B2).
Short Description
This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse format, created for improved compatibility with existing reagents, assays and techniques.
AB04911-3.3-BT Datasheet
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