Anti-C3D [AbAbC3D], Human IgG1, lambda
Catalogue Number: AB05051-10.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | C3; CPAMD1; Complement C3; Complement C3d fragment; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Human |
| Clone: | AbAbC3D |
| Isotype: | IgG1 |
| Immunogen: | This antibody was raised by panning a human single-chain antibody library against human C3d. |
| Application: | ELISA, InVitroA, InVivoA, SPR |
Additional Text
Gene Name
C3
Gene ID
718
Uniprot ID
P01024
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Short Description
This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Application Notes
The specificity of this antibody was determined using it for an ELISA on C3D. A fusion protein of this antibody with CD59 was used for surface plasmon resonance on C3dg-biotin. This antibody was tested for its ability to inhibit the complement in vitro, it showed inhibitory activity. A fusion protein of this antibody with CD59 was used in vivo on a rheumatoid arthritis mouse model, it showed the ability to inhibit inflammation in a dose-dependent relationship, further it also showed improved survivability in MRL/lpr lupus erythematosus mice (WO2021109968A1).
AB05051-10.0 Datasheet
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