Anti-CD70 [2H7], Human IgG1, kappa

Catalogue Number: AB05056-10.0-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD27-L; CD27LG; TNFSF7; CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Human
Clone:	2H7
Isotype:	IgG1
Immunogen:	This antibody was raised by immunizing HuMab mice with recombinant human CD70.
Application:	FC, InVitroA

Overview
Datasheets

Additional Text

Gene Name

CD70

Gene ID

970

Uniprot ID

P32970

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody was used to create a antibody drug conjugate with glucocorticoid payloads, it was used for a cellular assay using CD70-positive 786-O cells, it was shown that the antibody drug conjugate can increase GILZ mRNA expression in these cells (Kern et al., 2016; PMID:27469406, Kern et al., 2016; PMID:26745435). The uncialamycin ADC version of this antibody was tested for its ability to inhibit proliferation of 786-O cells, it showed that it was able to with IC50 partially dependent on the linker used (Chowdari et al., 2019; PMID:30579797). The original antibody was used for flow cytometry on human CD4 positive cells to determine receptor density (Mazor et al., 2015; PMID:25730144).

AB05056-10.0 Datasheet

Price

£430.00

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