Anti-FLT3 [A3], Mouse IgG2b, kappa
Catalogue Number: AB05077-3.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD135; FLK-2; FLT-3; STK-1; Fetal liver kinase 2; FL cytokine receptor; stem cell tyosine kinase 1; Fms-like tyrosine kinase 3; Receptor-type tyrosine-protein kinase FLT3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | A3 |
| Isotype: | IgG2b |
| Immunogen: | The original antibody was isolated from a human scFv phage display library by panning against ECD of human or mouse recombinant FLT3. |
| Application: | ELISA, Inh, InVivoA, Ant |
Additional Text
Gene ID
2322
Gene Name
FLT3
Uniprot ID
P36888
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Short Description
This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Application Notes
This antibody binds the extracellular domain of the recombinant human and mouse FLT3 in an ELISA. It inhibits binding of FLT3 ligand to recombinant human and mouse full-length FLT3 expressed in HEK293 cells. This antibody antagonizes FLT3 ligand-induced FLT3 activation in RS4-11 cells. It inhibits FLT3 ligand-induced FLT3 autophosphorylation at concentrations of 10 and 100 µg/ml. It was reported to be potent at antagonizing native FLT3 in sensory neurons and efficacious in inhibiting neuropathic pain in a Chronic Constriction Injury (CCI) murine model (US10781452).
AB05077-3.0 Datasheet
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