Anti-LASV glycoprotein complex [M30], Human IgG1, kappa
Catalogue Number: AB05116-10.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Lassa virus glycoprotein complex; GPC; Pre-glycoprotein polyprotein GP complex; Pre-GP-C; Stable signal peptide; SSP; Glycoprotein G1; GP1; Glycoprotein G2; GP2; 18.5C/R59ins-L108R; 18.5C-M30 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | M30 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by introducing two mutations (R54 insertion and L100R) into the sequence of the parent clone 18.5C (an isolate from a human survivor of Lassa fever). |
| Application: | ELISA, EM, NT, InVitroA |
Additional Text
Purification
Purified
UniProt ID
P08669
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Gene ID
956585
Gene Name
LASVsSgp2
Application Notes
The original antibody (human IgG1) was generated and shown to completely neutralize 100% of rVSV-LASV-LI particles with an IC50 of 2-4 nM. It also completely neutralized authentic LASV-LI in a Plaque-Reduction Neutralization Test (PRNT) (Hastie et al., 2019; PMID: 31398326). BLI characterization revealed high binding affinity, with apparent KD values of 0.559 nM, 0.494 nM, 0.154 nM, and 47.0 pM for LASV lineage I (LI) GP, LI-R198S-GP, LI-Q397H-GP, and LASV lineage IV (LIV) GP, respectively (Buck et al., 2022; PMID: 35730904).
AB05116-10.0-BT Datasheet
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