Anti-LASV glycoprotein complex [M30], Rabbit IgG, kappa
Catalogue Number: AB05116-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Lassa virus glycoprotein complex; GPC; Pre-glycoprotein polyprotein GP complex; Pre-GP-C; Stable signal peptide; SSP; Glycoprotein G1; GP1; Glycoprotein G2; GP2; 18.5C/R59ins-L108R; 18.5C-M30 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | M30 |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated by introducing two mutations (R54 insertion and L100R) into the sequence of the parent clone 18.5C (an isolate from a human survivor of Lassa fever). |
| Application: | ELISA, EM, NT, InVitroA |
Additional Text
Purification
Purified
UniProt ID
P08669
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Gene ID
956585
Gene Name
LASVsSgp2
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Application Notes
The original antibody (human IgG1) was generated and shown to completely neutralize 100% of rVSV-LASV-LI particles with an IC50 of 2-4 nM. It also completely neutralized authentic LASV-LI in a Plaque-Reduction Neutralization Test (PRNT) (Hastie et al., 2019; PMID: 31398326). BLI characterization revealed high binding affinity, with apparent KD values of 0.559 nM, 0.494 nM, 0.154 nM, and 47.0 pM for LASV lineage I (LI) GP, LI-R198S-GP, LI-Q397H-GP, and LASV lineage IV (LIV) GP, respectively (Buck et al., 2022; PMID: 35730904).
AB05116-23.0 Datasheet
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