Functional LTbetaR (mouse) Antibody, mAb
Catalogue Number: ADP0020-ABG
| Manufacturer: | Abcepta |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Lymphotoxin-β Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | |
| Clone: | 4H8 WH2 |
| Isotype: | |
| Immunogen: | |
| Application: | FC |
Description
Description: The LT-β-R activates two different NF-kappa pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LT-β-R activates the classical NF-kappa (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1-β-. However, LT-β-R, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Additional Text
Concentration
1 mg/ml
Antibody Clonality
Monoclonal
ADP0020 Datasheet
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