Catalogue Number: AF0015-AFF
Manufacturer: | Affinity Biosciences Ltd |
Shelf Life: | 12 months |
Preservative: | Azide |
Ph: | 7.4 |
Physical state: | Liquid |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | RYR2 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ul, 200 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | A synthesized peptide derived from human RYR2, corresponding to a region within the internal amino acids. |
Application: | WB, IHC |
Description: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
1 mg/ml
RYR2
6262
564 kDa
Q92736
Affinity Purified
Polyclonal