Phospho-EPHA2/3/4 (Tyr588/Tyr596) Antibody
Catalogue Number: AF0028-AFF
| Manufacturer: | Affinity Biosciences Ltd |
| Shelf Life: | 12 months |
| Preservative: | 0.02% sodium azide |
| Molecular Weight: | 130kDa |
| Ph: | 7.4 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | EPHA2 ECK |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A synthesized peptide derived from human EPHA2/3/4 around the phosphorylation site of Tyr588 and 596. |
| Application: | ICC, IF, WB, IHC, pELISA |
Description
Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
Additional Text
Molecular Weight
130kDa
Concentration
1 mg/ml
Modification
Phosphorylated, Tyr588
Gene ID
1969; 2042; 2043
Uniprot ID
P29317, P29320, P54764
Gene Name
EPHA2, EPHA3, EPHA4
Antibody Clonality
Polyclonal
Purification
Affinity Purified; Sequential Chromatography
Storage Note
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
AF0028 Datasheet
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