Goat Anti-Androgen Receptor Antibody
Catalogue Number: AF1061A-ABG
AF1061a Image
AF1061a Image
AF1061a Image
AF1061a Image
AF1061a(0.3 µg/ml) staining of Human Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
AF1061a Image
AF1061a (2 µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
AF1061a Image
ChIP of 2ug AF1061a with 1ug DHT-treated HEC50 chromatin using the using the Chromatrap® spin column sonication kit (Protein G) measuring FKBP5 enrichment.
| Manufacturer: | Abcepta |
| Type: | ChIP Validated Antibodies |
| Alias: | Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA, ChIP, WB, IHC |
Description
Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Additional Text
Gene Name
AR
Gene ID
367
Uniprot ID
P10275
Accession Number
NP_000035
Antigen Type
Synthetic Peptide
Antibody Clonality
Polyclonal
Short Description
Peptide-affinity purified goat antibody
Concentration
0.5 ug/ml
AF1061a Datasheet
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