VHL, Biotinylated
Catalogue Number: AF2146B-ABG
| Manufacturer: | Abcepta |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | WB, pELISA |
Description
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Additional Text
Antigen Type
Synthetic Peptide
Gene ID
7428
Accession Number
NP_937799
Uniprot ID
P40337
Antibody Clonality
Polyclonal
Gene Name
VHL
Short Description
Peptide-affinity purified goat antibody
Concentration
0.5 ug/ml
AF2146B Datasheet
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