Catalogue Number: AF5402-AFF
Manufacturer: | Affinity Biosciences Ltd |
Shelf Life: | 12 months |
Preservative: | Azide |
Ph: | 7.4 |
Physical state: | Liquid |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | MAP1LC3B MAP1ALC3 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ul, 200 ul, 20 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | A synthesized peptide derived from human LC3B, corresponding to a region within N-terminal amino acids. |
Application: | ICC, IF, WB, IHC, pELISA |
Description: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
1 mg/ml
Affinity Purified
Polyclonal
14kDa,16 kDa
Q9GZQ8, Q9H492
81631; 84557
MAP1LC3A, MAP1LC3B