Catalogue Number: AF5404-AFF
Manufacturer: | Affinity Biosciences Ltd |
Shelf Life: | 12 months |
Preservative: | 0.02% sodium azide |
Molecular Weight: | 45 kDa |
Ph: | 7.4 |
Physical state: | Liquid |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | DMTN DMT EPB49 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ul, 200 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | A synthesized peptide derived from human Dematin, corresponding to a region within C-terminal amino acids. |
Application: | ICC, IF, WB, IHC, pELISA |
Description: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
1 mg/ml
2039
45 kDa
Q08495
DMTN
Affinity Purified
Polyclonal
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.