Cyclin H Antibody
Catalogue Number: AF5406-AFF
| Manufacturer: | Affinity Biosciences Ltd |
| Shelf Life: | 12 months |
| Preservative: | 0.02% sodium azide |
| Molecular Weight: | 37.6 kDa |
| Ph: | 7.4 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | CCNH |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A synthesized peptide derived from human Cyclin H, corresponding to a region within C-terminal amino acids. |
| Application: | ICC, IF, WB, IHC, pELISA |
Description
Description: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Additional Text
Concentration
1 mg/ml
Gene ID
902
Gene Name
CCNH
Uniprot ID
P51946
Purification
Affinity Purified
Molecular Weight
37.6 kDa
Antibody Clonality
Polyclonal
Storage Note
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
AF5406 Datasheet
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