Cyclin D2 Antibody
Catalogue Number: AF5410-AFF
| Manufacturer: | Affinity Biosciences Ltd |
| Shelf Life: | 12 months |
| Preservative: | 0.02% sodium azide |
| Molecular Weight: | 33 kDa |
| Ph: | 7.4 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | CCND2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A synthesized peptide derived from human Cyclin D2, corresponding to a region within C-terminal amino acids. |
| Application: | ICC, IF, WB, pELISA |
Description
Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Additional Text
Gene Name
CCND2
Uniprot ID
P30279
Concentration
1 mg/ml
Gene ID
894
Molecular Weight
33 kDa
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Storage Note
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
AF5410 Datasheet
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