AGE, Advanced Glycation End Products
Catalogue Number: AGE102-1.0-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Shipping Condition: | RT |
| Unit(s): | 1 ml |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | |
| Immunogen: | Advanced Glycation End Products /BSA/HSA |
| Application: | ELISA |
Description
Description: This antibody is suitable for the detection of different AGE products in tissues, tissue extracts and body fluids. Long-term incubation of proteins with glucose leads, through Schiff's base and Amadori rearrangement products, to the formation of advanced glycation end products (AGE) which are characterized by fluorescence, brown color and inter- and intra-molecular cross-linking. Recent immunological studies using anti-AGE antibodies demonstrated the presence of AGE in (i) human lens, (ii) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (iii) atherosclerotic lesions of arterial walls, (iv) β2-microglobulin of carpal tunnel amyloid fibril deposits in patients with hemodialysis-related amyloidosis and (v) brain tissues of patients with Alzheimer's disease. These results suggested the potential role of AGE in normal aging and age-enhanced disease processes. Advanced Glycation End Products (AGE), cross-reactivity BSA and HSA <1%.
Additional Text
Concentration
0.5 mg/ml
Purification
Protein A purified
Antibody Clonality
Polyclonal
Storage Note
-20°C
Application Notes
ELISA, IHC not established
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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