CD195 (CC-Chemokine Receptor 5) Antibody - With BSA and Azide
Catalogue Number: AH11102-ABG
| Manufacturer: | Abcepta |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5, CHEMR13, HIV-1 fusion coreceptor, CD195, CCR5, CMKBR5 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 20 ug, 100 ug |
| Host name: | Mouse |
| Clone: | 12D1 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, IF, IHC-Fr |
Description
Description: Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Additional Text
Gene Name
CCR5
Uniprot ID
P51681
Gene ID
1234
Antibody Clonality
Monoclonal
Short Description
Mouse Monoclonal Antibody [Clone 12D1 ]
AH11102 Datasheet
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