Laminin, gamma 1 (LAMC1) Antibody - With BSA and Azide

Catalogue Number: AH11743-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	20 ug, 100 ug
Host name:	Rat
Clone:	A5
Isotype:
Immunogen:
Application:	FC, IF, IHC

Overview
Datasheets

Description

Description: Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of α, β, and γ chains. This MAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.

Additional Text

Gene Name

LAMC1

Gene ID

3915

Antibody Clonality

Monoclonal

Specificity

Laminin subunit gamma-1, Laminin B2 chain, Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, Laminin-3 subunit gamma, Laminin-4 subunit gamma, Laminin-6 subunit gamma, Laminin-7 subunit gamma, Laminin-8 subunit gamma, Laminin-9 subunit gamma, S-laminin subunit gamma, S-LAM gamma, LAMC1, LAMB2

Uniprot ID

P11047, Q5VYE7, Q6NVY8

Short Description

Rat Monoclonal Antibody [Clone A5 ]

AH11743 Datasheet

Price

£231.00

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