RICTOR Antibody (C-Terminus)
Catalogue Number: ALS11206-ABG
| Manufacturer: | Abcepta |
| Molecular Weight: | 192218 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Rapamycin-insensitive companion of mTOR, AVO3 homolog, hAVO3, RICTOR {ECO:0000312|EMBL:EAW55980.1} |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA, IHC-P |
Description
Description: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Additional Text
Uniprot ID
Q6R327
Concentration
0.5 mg/ml
Gene ID
253260
Antigen Type
Synthetic Peptide
Molecular Weight
192218
Storage Note
Store at -20°C. Minimize freezing and thawing.
Short Description
Goat Polyclonal Antibody
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Gene Name
Rictor
ALS11206 Datasheet
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