GAPDH Antibody (aa51-290)
Catalogue Number: ALS11545-ABG
| Manufacturer: | Abcepta |
| Molecular Weight: | 36053 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, 1.2.1.12, Peptidyl-cysteine S-nitrosylase GAPDH, 2.6.99.-, GAPDH, GAPD |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Chicken |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | IHC-P, WB, IHC |
Description
Description: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D- glyceroyl phosphate. Component of the GAIT (gamma interferon- activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
Additional Text
Gene Name
GAPDH
Concentration
0.5 mg/ml
Gene ID
2597
Antigen Type
Recombinant Protein
Molecular Weight
36053
Storage Note
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Uniprot ID
P04406
Short Description
Chicken Polyclonal Antibody
Purification
Affinity Purified
Antibody Clonality
Polyclonal
ALS11545 Datasheet
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