AIRE Antibody (C-Terminus)
Catalogue Number: ALS11887-ABG
| Manufacturer: | Abcepta |
| Molecular Weight: | 57727 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein, AIRE, APECED |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA, IHC-P, RIA |
Description
Description: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Additional Text
Gene Name
AIRE
Gene ID
326
Uniprot ID
O43918
Concentration
0.5 mg/ml
Antigen Type
Synthetic Peptide
Molecular Weight
57727
Storage Note
Store at -20°C. Minimize freezing and thawing.
Short Description
Goat Polyclonal Antibody
Purification
Affinity Purified
Antibody Clonality
Polyclonal
ALS11887 Datasheet
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