EGFR Antibody (Internal)
Catalogue Number: ALS12167-ABG
| Manufacturer: | Abcepta |
| Molecular Weight: | 134277 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Epidermal growth factor receptor, 2.7.10.1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA, ICC, IF, IHC-P, IP, WB |
Description
Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
Additional Text
Gene ID
1956
Concentration
0.5 mg/ml
Gene Name
EGFR
Uniprot ID
P00533
Antigen Type
Recombinant Protein
Molecular Weight
134277
Storage Note
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Purification
Protein G purified
Short Description
Sheep Polyclonal Antibody
Antibody Clonality
Polyclonal
ALS12167 Datasheet
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