EBI3 Antibody (clone DNT27)
Catalogue Number: ALS14238-ABG
| Manufacturer: | Abcepta |
| Molecular Weight: | 25396 |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, IL27B |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rat |
| Clone: | DNT27 |
| Isotype: | |
| Immunogen: | |
| Application: | IHC-P, WB, IHC |
Description
Description: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Additional Text
Gene Name
EBI3
Concentration
0.5 mg/ml
Gene ID
10148
Molecular Weight
25396
Storage Note
Store at 4°C, avoid repeated freeze thaw cycles.
Uniprot ID
Q14213
Short Description
Rat Monoclonal Antibody
Purification
Affinity Purified
Antibody Clonality
Monoclonal
ALS14238 Datasheet
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