SLC3A2 / CD98 Heavy Chain Antibody (clone 10.7)
Catalogue Number: ALS16308-ABG
| Manufacturer: | Abcepta |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | 4F2 cell-surface antigen heavy chain, 4F2hc, 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, Solute carrier family 3 member 2, CD98, SLC3A2, MDU1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Armenian Hamster |
| Clone: | 10.7 |
| Isotype: | |
| Immunogen: | |
| Application: | IHC-P, IP, WB |
Description
Description: Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
Additional Text
Concentration
1 mg/ml
Gene Name
SLC3A2
Uniprot ID
P08195
Gene ID
6520
Molecular Weight
67994
Antigen Type
Purified protein
Storage Note
Store at -20°C.
Purification
Protein A purified
Antibody Clonality
Monoclonal
Short Description
Armenian Hamster Monoclonal Antibody
ALS16308 Datasheet
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