PRDM2 (RIZ1) Antibody
Catalogue Number: AM1194A-ABG
AM1194a Image
AM1194a Image
AM1194a Image
AM1194a Image
AM1194a Image
ChIP analysis of estrogen target genes. (C) ChIP analysis was performed on RIZ1 knockout mouse embryonic fibroblasts by using anti-RIZ1 antibody (AM1194a). Immunoprecipitated chromatin DNA was analyzed by PCR with primers in the G6pd promoter region and in the cdc25c promoter region. Adapted from Fig 6 in Carling et al., 2004 (see citation 2).
AM1194a Image
ChIP analysis of estrogen target genes.(B) Time course analysis of RIZ1 binding to the pS2 gene promoter. MCF7 cells treated with E2 for different periods of time, as indicated at the top of each lane, were processed for ChIP analysis. Immunoprecipitation was performed with antibody to RIZ1 (AM1194a) and control immunoglobulin G as indicated. Adapted from Fig 6 in Carling et al., 2004 (see citation 2).
AM1194a Image
ChIP analysis of estrogen target genes. (A) Soluble chromatin was prepared from MCF7 cells not treated or treated with E2 for 45 min. Immunoprecipitation was performed with antibody against RIZ1 (AM1194a). DNA extractions were amplified by using primer sets that cover the pS2 gene promoter region or the GAPDH gene promoter. Adapted from Fig 6 in Carling et al., 2004 (see citation 2).
AM1194a Image
Western blot analysis of anti-PRDM2 Mab (Cat. #AM1194a) in lysate from PRDM2 transgenic lysate.Secondary HRP-anti-mouse was used for signal visualization with chemiluminescence.
| Manufacturer: | Abcepta |
| Molecular Weight: | 188915 |
| Type: | ChIP Validated Antibodies |
| Alias: | PR domain zinc finger protein 2, GATA-3-binding protein G3B, Lysine N-methyltransferase 8, MTB-ZF, MTE-binding protein, PR domain-containing protein 2, Retinoblastoma protein-interacting zinc finger protein, Zinc finger protein RIZ, PRDM2, KMT8, RIZ |
| Shipping Condition: | Blue Ice |
| Unit(s): | 400 ul, 80 ul |
| Host name: | Mouse |
| Clone: | 33AT1045 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | ChIP, WB |
Description
Description: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
Additional Text
Uniprot ID
Q13029
Gene ID
7799
Gene Name
PRDM2
Molecular Weight
188915
Antibody Clonality
Monoclonal
Accession Number
NP_001007258.1,,NP_001129082.1,,NP_036363.2,,NP_056950.2
Short Description
Purified Mouse Monoclonal Antibody (Mab)
Preparation
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
AM1194a Datasheet
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