GSTA1 Antibody (ascites)
Catalogue Number: AM1932A-ABG
| Manufacturer: | Abcepta |
| Molecular Weight: | 25631 |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Glutathione S-transferase A1, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, N-terminally processed, GSTA1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 ml |
| Host name: | Mouse |
| Clone: | 286CT8.1.5 |
| Isotype: | IgM, kappa |
| Immunogen: | |
| Application: | WB |
Description
Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
Additional Text
Gene Name
GSTA1
Uniprot ID
P08263
Accession Number
NP_665683.1
Gene ID
2938
Antigen Type
Recombinant Protein
Molecular Weight
25631
Antibody Clonality
Monoclonal
Short Description
Mouse Monoclonal Antibody (Mab)
Preparation
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
AM1932a Datasheet
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