IGHD Antibody (N-term) (Ascites)
Catalogue Number: AM2141A-ABG
| Manufacturer: | Abcepta |
| Molecular Weight: | 47500 |
| Type: | Monoclonal Secondary Antibody - Unconjugated |
| Alias: | Ig delta chain C region, IGHD |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 ml |
| Host name: | Mouse |
| Clone: | 607CT8.4.4 |
| Isotype: | IgM |
| Immunogen: | |
| Application: | WB |
Description
Description: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Additional Text
Uniprot ID
P01880
Antigen Type
Synthetic Peptide
Antibody Clonality
Monoclonal
Molecular Weight
42353
Short Description
Mouse Monoclonal Antibody (Mab)
Preparation
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
AM2141a Datasheet
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