GPR56 Antibody
Catalogue Number: AM8687B-ABG
AM8687B Image
AM8687B Image
All lanes : Anti-GPR56 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: U87-MG whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 78 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
| Manufacturer: | Abcepta |
| Molecular Weight: | 77738 |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 400 ul, 80 ul |
| Host name: | Mouse |
| Clone: | 1443CT642.85.27 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | WB |
Description
Description: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.
Additional Text
Gene ID
9289
Uniprot ID
Q9Y653
Molecular Weight
77738
Specificity
G-protein coupled receptor 56, Protein TM7XN1, GPR56 N-terminal fragment, GPR56 NT, GPR56(N), GPR56 extracellular subunit, GPR56 subunit alpha, GPR56 C-terminal fragment, GPR56 CT, GPR56(C), GPR56 seven-transmembrane subunit, GPR56 7TM, GPR56 subunit beta, GPR56, TM7LN4, TM7XN1
Antibody Clonality
Monoclonal
Gene Name
ADGRG1
Short Description
Purified Mouse Monoclonal Antibody (Mab)
AM8687B Datasheet
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