RAB13 Antibody
Catalogue Number: AM8693B-ABG
AM8693B Image
AM8693B Image
All lanes : Anti-RAB13 Antibody at 1:1000 dilution Lane 1: MCF-7 whole cell lysate Lane 2: A431 whole cell lysate Lane 3: A549 whole cell lysate Lane 4: U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 23 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
| Manufacturer: | Abcepta |
| Molecular Weight: | 22774 |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Ras-related protein Rab-13, Cell growth-inhibiting gene 4 protein, RAB13 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ul, 50 ul |
| Host name: | Mouse |
| Clone: | 1600CT724.2.34 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | WB |
Description
Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Additional Text
Uniprot ID
P51153
Gene ID
5872
Antigen Type
Recombinant Protein
Molecular Weight
22774
Antibody Clonality
Monoclonal
Gene Name
RAB13
Short Description
Purified Mouse Monoclonal Antibody (Mab)
AM8693B Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations