Pancreatic polypeptide/PPY Polyclonal Antibody

Catalogue Number: AN000330P-ELA

Manufacturer:Elabscience
Preservative:0.05% ProClin™ 300
Type:Polyclonal Primary Antibody - Unconjugated
Alias:Pancreatic poLypeptide prohormone;PH;Pancreatic poLypeptide Y;Pancreatic poLypeptide;Pancreatic icosapeptide;PPY;PNP
Shipping Condition:Blue Ice
Unit(s): 1 mg, 100 ug, 25 ug
Host name: Rat
Clone:
Isotype: IgG
Immunogen: Recombinant Human Pancreatic polypeptide/PPY protein expressed by E.coli
Application: ELISA

Description

Description: Pancreatic polypeptide (PP),36-amino acid peptide,may function as an important feedback inhibitor of pancreatic secretion after a meal. It arises from both islet and acinar cells of the pancreas. Release of PP by a meal,primarily protein,occurs in a biphasic manner. PP is a negative regulator of energy homeostasis that suppresses food intake and lowers body weight. Similar to other gastrointestinal-derived peptides,PP also modulates gastrointestinal motility and may be involved in the regulation of anxiety. PP,a robust anorexigenic hormone,effectively modulates food intake and energy homeostasis,thus potentially aiding anti-obesity therapeutics. PP is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand,central administration of PP elicits food intake and gastric emptying.

Additional Text

Gene ID

5539

Uniprot ID

P01298

Gene Name

Ppy

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Concentration

1 mg/ml

Storage Note

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Price
£1,410.00


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