HRP-conjugated Lamin A/C Monoclonal Antibody

Catalogue Number: AN00298HP-ELA

Manufacturer:	Elabscience
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Prelamin-A/C;LMNA;LMN1;Lamin A/C
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Mouse
Clone:	4F1
Isotype:	IgG1
Immunogen:	Recombinant Human Lamin A/C protein expressed by E.coli
Application:	WB

Overview
Datasheets

Description

Description: Lamin A/C is also named as LMNA,or LMN1. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis,the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability,chromatin structure and gene expression. The lack of lamin A/C can be as a novel marker for undifferentiated embryonic stem cells and lamin A/C expression is as an early indicator of differentiation (PMID: 16179429). Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy,familial partial lipodystrophy,limb girdle muscular dystrophy,dilated cardiomyopathy,Charcot-Marie-Tooth disease,and Hutchinson-Gilford progeria syndrome. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kDa,65 kDa,70 kDa and 64 kDa. This antibody can recognize 4 isoforms of Lamin A/C.

Additional Text

Gene Name

LMNA

Gene ID

4000

Uniprot ID

P02545

Antibody Clonality

Monoclonal

Concentration

1 mg/ml

Purification

Protein A/G Purification

Storage Note

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.

AN00298HP Protocol

AN00298HP MSDS

Price

£150.00

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