AF/LE Purified Anti-Mouse CD3e Antibody[500A2]
Catalogue Number: AN003420-ELA
| Manufacturer: | Elabscience |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | T-cell surface glycoprotein CD3 epsilon chain;CD3E;T-cell surface antigen T3/Leu-4 epsilon chain;CD3e;CD3E;T3E |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 mg, 100 ug, 25 mg, 25 ug, 5 mg, 50 mg |
| Host name: | Syrian Hamster |
| Clone: | 500A2 |
| Isotype: | IgG |
| Immunogen: | |
| Application: | FC |
Description
Description: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region
Additional Text
Gene Name
CD3E
Gene ID
12501
Uniprot ID
P22646
Antibody Clonality
Monoclonal
Concentration
>=1 mg/ml
Storage Note
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
SUPPORT
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DELIVERY
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