Phospho-INSR(Y1361) Antibody
Catalogue Number: AP3134A-ABG
AP3134A Image
AP3134A Image
AP3134A Image
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
AP3134A Image
Dot blot analysis of anti-INSR-pY1361 Pab (Cat. #AP3134a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
| Manufacturer: | Abcepta |
| Molecular Weight: | 156333 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Insulin receptor, IR, CD220, Insulin receptor subunit alpha, Insulin receptor subunit beta, Insr |
| Shipping Condition: | Blue Ice |
| Unit(s): | 400 ul, 80 ul |
| Host name: | Rabbit |
| Clone: | RB7155 |
| Isotype: | IgG |
| Immunogen: | |
| Application: | IHC-P, WB, DB |
Description
Description: After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1.
Additional Text
Uniprot ID
P06213
Gene ID
3643
Antigen Type
Synthetic Peptide
Molecular Weight
156333
Antibody Clonality
Polyclonal
Accession Number
NP_000199.2,,NP_001073285.1
Gene Name
INSR
Short Description
Affinity Purified Rabbit Polyclonal Antibody (Pab)
Preparation
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
AP3134A Datasheet
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