erbB-2 Antibody
Catalogue Number: ASC10899-ABG
ASC10899 Image
ASC10899 Image
ASC10899 Image
ASC10899 Image
Western blot analysis of erbB-2 in rat liver tissue lysate with erbB-2 antibody at (A) 1 and (B) 2 µg/mL.
ASC10899 Image
Immunohistochemistry of erbB-2 in human liver tissue with erbB-2 antibody at 2.5 µg/mL.
ASC10899 Image
Immunofluorescence of ERBB2 in human liver tissue with ERBB2 antibody at 20 µg/mL.
| Manufacturer: | Abcepta |
| Shelf Life: | 12 months |
| Molecular Weight: | 137910 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Chicken |
| Clone: | |
| Isotype: | IgY |
| Immunogen: | |
| Application: | ELISA, IF, IHC-P, IP, WB, IHC |
Description
Description: erbB-2 Antibody: The ErbB family consists of four closely related tyrosine kinase receptors that act as potent mediators of normal cell growth and development. Aberrant expression or function of one or more of these receptors can play a major role in the development and evolution of cancer. ErbB-2, also known as HER2, has been implicated in the evolution of both breast and gastric cancers, and is evident in other cancer types such as ovarian and salivary gland tumors. ErbB-2 possesses an active tyrosine kinase domain, but no direct ligand has been identified yet. ErbB-2 is the preferred binding partner to the other members of the ErbB family and is thought to act primarily through the Ras-MAPK, PI3k-PKB/Akt, and PLC-PKC signaling pathways. Numerous anti-cancer strategies have been employed against erbB-2, such as antibody-based therapies to prevent ligand binding or receptor activation through dimerization, antibody-dependent cell mediated cytotoxicity, in addition to direct kinase inhibition to prevent molecular activation/downstream signaling.
Additional Text
Gene ID
2064
Gene Name
ERBB2
Uniprot ID
P04626
Molecular Weight
137910
Application Notes
erbB-2 antibody can be used for detection of erbB-2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Accession Number
NP_004439
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Storage Note
erbB-2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ASC10899 Datasheet
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