LDL-R Antibody
Catalogue Number: ASC10904-ABG
ASC10904 Image
ASC10904 Image
ASC10904 Image
ASC10904 Image
Western blot analysis of LDL-R in human liver tissue lysate with LDL-R antibody at (A) 1 and (B) 2 µg/mL.
ASC10904 Image
Immunohistochemistry of LDL-R in human liver tissue with LDL-R antibody at 2.5 µg/mL.
ASC10904 Image
Immunofluorescence of LDLR in human liver tissue with LDLR antibody at 20 µg/mL.
| Manufacturer: | Abcepta |
| Shelf Life: | 12 months |
| Molecular Weight: | 95376 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Chicken |
| Clone: | |
| Isotype: | IgY |
| Immunogen: | |
| Application: | ELISA, IF, IHC-P, WB, IHC |
Description
Description: LDL-R Antibody: The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
Additional Text
Gene Name
LDLR
Gene ID
3949
Uniprot ID
P01130
Molecular Weight
95376
Application Notes
LDL-R antibody can be used for detection of LDL-R by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Accession Number
NP_000518
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Storage Note
LDL-R antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ASC10904 Datasheet
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